本片为2001年在《猫狗大战》的续集。故事发生在距离上一次猫咪和狗狗的大战已经过去了数年之后。来之不易的和平再一次受到威胁。这次的敌人可不是上一部中的笨蛋，日本它可是原猫咪间谍组织“喵”（MEOWS）的顶级特工，日本名为Kitty Galore。它顺利地窃取到了狗狗组织的核心机密，并且为了报复狗狗组织和人类，它设计了一个恐怖而毒辣的计划意图控制全世界！在面对这样一个迫在眉睫且前所未有的致命威胁的紧要关头，猫与狗在万不得已的情况下，只能被迫选择结成同盟——这还是这两种生物历史上的第一次，在这个由一只猫所制造的浩劫当中，它们需要拯救的不仅仅是自己，还有他们深爱着的人类。为了阻挠邪恶计划的征途，它们必须得将身体里潜藏的一切生物本能发挥到极致才行……
回复 :San Francisco Tong hatchet man Wong must execute his boyhood friend Sun. Sun knew his time was up and wrote out his will just prior to Wong showing up at his door. When Sun realizes Wong is there to kill me he tries to set his friend's mind at ease by telling him he is the beneficiary of all Sun's worldly possessions and convinces Wong to promise to take care of Sun's young daughter, Toya San who Sun has bequeathed to become his wife. Years later, when she becomes of age, she marries Wong, now a powerful figure, though she loves evil Harry. When Wong learns Toya will be happier with Harry he allows them to leave. Still later Wong learns that Harry has been deported and since Toya could not prove she was married to someone else she too was deported to China. When Wong learns of this, he goes after them.
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回复 :莎莎，一位美丽的年轻摄影师，发现她的情人，一个成功的艺术家，被谋杀了。警察怀疑她，凶手们想让她安静下来。当她试图解决这个秘密的时候，她开始四处奔跑。
